It's feared more than half of the stock of carp in the Lough have died.
An investigation is underway after an outbreak of a fungal or bacterial infection killed and infected fish.
Inland Fisheries Ireland on Friday responded to calls of a number of dead fish at the Lough and estimates that up to 200 carp have been infected by the outbreak.
They're calling on anglers to stop all fishing activity at The Lough until further notice.
Any anglers who have been fishing the iconic lough in the last month are being asked to disinfect their fishing gear to prevent the spreak of disease.
The Evening Echo reports up to 150 fish were removed from the Lough over the course of the weekend and tests are being carried out to determine the cause of the outbreak
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